Selected Publications

Fletcher, S.P., Chin, D.J., Gruenbaum, L., Bitter, H., Rasmussen, E., Ravindran, P., Swinney, D.C., Birzele, F., Schmuki, R., Lorenz, S., Kopetzki, E., Carter, J., Triyatni, M., Thampi, L.M. Yang, J., AlDeghaither, D., Murredu, M.G., Cote, P. and Menne, S. (2016). Intrahepatic transcriptional signature associated with response to interferon-alpha treatment in the woodchuck model of chronic hepatitis B. PLOS Pathgens.
PMID:27022978

Lansita J. A., Burke J. M., Apgar J. F., Mounho-Zamora B. (2015). An Introduction to the Regulatory and Nonclinical Aspects of the Nonclinical Development of Antibody Drug Conjugates. Pharmaceutical Research.
PMID:26108879

Ducret, A., Kux van Geijtenbeek, S., Rder, D., Simon, S., Chin, D., Berrera, M., Gruenbaum, L., Ji, C., Cutler, P. (2015). Identification of six cell surface proteins for specific liver targeting. Proteomics Clinical Applications.
PMID:26097162

Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N. (2015). BI 885578, a novel IGF1R/INSR tyrosine kinase inhibitor with pharmacokinetic properties that dissociate anti-tumor efficacy and perturbation of glucose homeostasis. Molecular Cancer Therapeutics.
PMID:26438154

AM Clark, JT Borenstein, M. Ebrahimkhani, I. Fox, L. Griffith, W. Inman, D. Lauffenburger, T. Nguyen, R. Prantil-Baun, D. Stolz, D. Taylor, T. Ulrich, C. Pillai, R. Venkataramanan, A. Wells, SE Wheeler, C. Young (2014). A Microphysiological System Model of Metastasis Therapy. Experimental Biology and Medicine.
PMID:24821820

Tan, A.T., Hoang, T.L., Chin, D., Rasmussen, E., Lopatin, U., Bitter, H.M., Chu, T., Gruenbaum, L., Gane, E., Lim, S.G., Chow, W.C., Chen, P., Petric, R., Bertoletti, A., Hibberd, M.L. (2014). Reduction of HBV replication prolongs the early immunological response to IFNalpha therapy. Journal of Hepatology.
PMID:23994382

3. M. R. Ebrahimkhani, C. L. Young, D. A. Lauffenburger, L. G. Griffith, J. T. Borenstein (2014). Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discovery Today.
PMID:24821820

1. S. E. Wheeler, A. M. Clark, D. P. Taylor, C. L. Young, V. C. Pillai, D. B. Stolz, R. Venkataramanan, D. Lauffenburger, L. Griffith, A. Wells (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. British Journal of Cancer.
PMID:25314052

C. L. Young, D. L. Raden, A. S. Robinson (2013). Analysis of Endoplasmic Reticulum Resident Proteins in S. cerevisiae: Implementation of H/KDEL Retrieval Sequences. Traffic.
PMID:23324027

JT Borenstein, AM Clark, M. Ebrahimkhani, I. Fox, L. Griffith, W. Inman, D. Lauffenburger, T. Nguyen, R. Prantil-Baun, D. Stoltz, D. Taylor, T. Ulrich, C. Venkateswaran, R. Venkataramanan, A. Wells, C. Young (2013). All-Human Microphysical Model of Metastasis Therapy. Stem Cell Research and Therapy.
PMID:24565274

Fletcher, S.P., Chin, D.J., Cheng, D.T., Ravindran, P., Bitter, H., Gruenbaum, L., Cote, P.J., Ma, H., Klumpp, K., and Menne, S. (2013). Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B. Hepatology.
PMID:22806943

Kirouac, D. C., Saez-Rodriguez, J., Swantek, J., Burke, J. M., Lauffenburger, D. A., and Sorger, P. L. (2012). Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Systems Biology.
PMID: 22548703

Baum, P., Schmid, R., Ittrich, C., Rust, W., Fundel-Clemens, K., Siewert, S, Baur, M., Mara, L., Gruenbaum, L.M., Eils, R., Kontermann, R., Roth, G., Gantner, F., Schnapp, A., Park, J., Weith, A., Quast, K. and Mennerich, D. (2010). Phenocopy a strategy to qualify chemical compounds during Hit-to_Lead and/or Lead Optimization. PLOS One.
PMID:21170314

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