Event Details
September 29th - October 1st, 2021 | Virtual
Applied BioMath Presense
Presentation: Mechanistic Strategies for Modeling Avidity: Application in the Design of Tumor Selective Bispecific Antibodies in Oncology
Presenter: Alison Betts, PhD, Vice President of Scientific Collaborations and Fellow of Modeling & Simulation, Applied BioMath
Presentation Time: Thursday, September 30th, at 8:50AM
Abstract:
- Definition of avidity and why it is important in the design of tumor-selective bispecific antibodies
- Use of modeling to help understand avidity, including interpreting dose titration curves and optimizing single-site binding affinities
- Extrapolating avidity from in vitro to in vivo conditions
- Case study examples: optimizing design of a 2+1 tumor-selective T cell engager bispecific antibody for binding selectivity to tumor cells