Event Details

September 29th - October 1st, 2021 | Virtual

Applied BioMath Presense

Presentation: Mechanistic Strategies for Modeling Avidity: Application in the Design of Tumor Selective Bispecific Antibodies in Oncology

Presenter: Alison Betts, PhD, Vice President of Scientific Collaborations and Fellow of Modeling & Simulation, Applied BioMath

Presentation Time: Thursday, September 30th, at 8:50AM

Abstract:

  • Definition of avidity and why it is important in the design of tumor-selective bispecific antibodies
  • Use of modeling to help understand avidity, including interpreting dose titration curves and optimizing single-site binding affinities
  • Extrapolating avidity from in vitro to in vivo conditions
  • Case study examples: optimizing design of a 2+1 tumor-selective T cell engager bispecific antibody for binding selectivity to tumor cells