Event Details

June 25 - 26, 2020

Applied BioMath Presence

Presentation: Targeting Bispecific Antibodies and Developing Systems Disease Models in I/O

Presentation Time: June 25th at 12:55PM

  • Systems pharmacology is a mathematical modeling and engineering approach to translational medicine that quantitatively integrates knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms.
  • Several examples will be shown that highlight mathematical modeling efforts to accelerate the discovery and development of best-in-class therapeutics and impact critical decisions, in the continuum from preclinical exploration to clinical research. 
  • Examples include, T cell engager at the new target through lead generation stage, GITR-mediated T cell dynamics, species translation to make human predictions, and mechanistic predictions in checkpoint inhibitors. 

Presenter: John M. Burke, PhD, Co-Founder, President and CEO, Applied BioMath