Event Details

April 30 - May 4, 2018 | Boston, MA

Applied BioMath Presence 

John M. Burke, PhD, Co-Founder, President, and CEO of Applied BioMath, is presenting "Model Aided Drug Invention Case Studies in Research and Development" Wednesday, May 2 at 3:15pm. In this presentation, Dr. Burke explains two studies that highlight examples of Model Aided Drug Invention (MADI) efforts, which include mechanistic pharmacokinetic and pharmacodynamic (PK/PD) and systems pharmacology approaches, that accelerated the discovery and development of best-in-class therapeutics and impacted critical decisions.

Additionally, Dr. Burke is presenting "Computational Exploration of Mechanistic Determinants of ADC Pharmacokinetics Using QSP Modeling Strategies" Thursday, May 3 at 9:35am. This presentation demonstrates how quantitative systems pharmacology (QSP) modeling approaches provide biological insights into the impact of drug-to-antibody (DAR) ratio and the resulting changes in molecular properties on overall pharmacokinetics and relative payload disposition as observed in preclinical studies.

During the conference, visit Applied BioMath at booth #643 and look for our poster "Quantitative Systems Pharmacology and Immunotherapy: Accelerating Lead Generation and Optimization of a PD-1 x TIM-3 Biotherapeutic in Immuno-Oncology" during poster session B, being held May 2-3, 2018.