Event Details

September 18-20, 2018

Boston, MA

Applied BioMath Presence

Presentation by Dr. John M. Burke

September 19, 2018 | 9:30-10:00AM

Presentation Title: Model Aided Drug Invention (MADI) Case Studies in Research: In Silico Differentiation for Dual Targeting PD-1 and Tim-3 in I/O, and Predicting Optimal Drug Properties of a Bispecific Biologic to Maximize Tissue Targeting in OA

Presentation Synopsis:

  1. MADI is a rigorous fit-for-purpose model development process which aims to quantitatively integrate knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms.
  2. Exploring two case studies that highlight examples of MADI efforts that have de-risked projects, accelerated the discovery and development of best-in-class therapeutics, and impacted critical decisions, in the continuum from preclinical exploration to clinical research.
  3. Integrating systems modeling to predict optimal drug properties targeting PD-1 and TIM3 in immuno-oncology for bispecific biologics and fixed dose combinations.
  4. Investigating MADI approaches to determine best in class properties for targeted anabolic growth factor to arthritic joints