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Applied BioMath, LLC Announces Participation at PBSS San Francisco Antibody Drug Conjugate Workshop

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to accelerate and de-risk drug research and development, today announced their participation as a sponsor at the Pharmaceutical and Bioscience Society (PBSS) San Francisco Antibody Drug Conjugate (ADC) workshop being held Wednesday September 12, 2018 at 8:45 a.m. at the SF Bay Area: Foster City Crowne Plaza in San Francisco, CA.

Applied BioMath, LLC Extends Collaboration into Phase 1 with Northern Biologics for Clinical Pharmacology Support and Semi-Mechanistic PK/PD Modeling Support in Oncology

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to accelerate and de-risk drug research and development, today announced an extension to their collaboration with Northern Biologics Inc. to include Phase I clinical analyses for MSC-1, their lead antibody therapeutic targeting the cytokine LIF for the treatment of cancer.

Applied BioMath, LLC Announces Collaboration with Revitope for Mechanistic PK/PD Modeling in Solid Tumors

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to de-risk and accelerate drug research and development, today announced a collaboration with Revitope for an in-vitro and human mechanistic PK/PD modeling of Revitope's bispecific T Cell Engaging Antibody Circuits (TEAC) targeting solid tumors.  "TEAC are designed to increase tumor specificity and launch an immune activation only when bound to the cancer cell surface.

Applied BioMath, LLC Announces Collaboration with Sanofi for Systems Pharmacology Modeling of Bispecific Antibody Therapeutics

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced a collaboration with Sanofi for the analysis of systems pharmacology pharmacokinetic (PK)/target engagement (TE) models for bispecific antibody combinations.  Applied BioMath will help assess the risk and feasibility of multispecific combinations and compare them to fixed dose combinations (FDC) for multiple targets.  These analyses will be used to help prioritize the portfolio and provide early screening criteria for lead generation.  

Applied BioMath, LLC announces collaboration with Sanofi for quantitative systems pharmacology modeling in immuno-oncology

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced a collaboration with Sanofi to develop quantitative systems pharmacology (QSP) models in immuno-oncology.   Applied BioMath will leverage its proprietary modeling platform to develop QSP pharmacokinetic (PK) and pharmacodynamics (PD) models for multiple therapeutics in both animal and human species.

Applied BioMath, LLC and CytomX Therapeutics, Inc. Announce a Continuation of their Collaboration for Quantitative Systems Pharmacology Modeling in Immuno-Oncology

Applied BioMath, the industry-leader in applying mechanistic modeling to drug research and development, today announced that CytomX has once again chosen Applied BioMath for the development of their semi-mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) models of human for immuno-oncology.  "Our choice of Applied BioMath for continued QSP model development reflects a track record of past successes with high-quality, innovative, and timely deliverables.

Applied BioMath, LLC awarded grant by National Institute on Aging of the NIH for the development of a systems pharmacology model in Alzheimer's Disease and Dementia

Applied BioMath, the industry-leader in applying mechanistic modeling to drug research and development, today announced that they have been awarded a grant for development of a quantitative systems pharmacology model of amyloid beta and tau pathways for clinical trial design and decision making in Alzheimer's Disease and Dementia.

Applied BioMath, LLC to Present at the Annual Drug Development Boot Camp

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced their participation at the annual Drug Development Boot Camp November 15-16, 2017 at the Harvard Club in Boston, MA. The Drug Development Boot Camp is hosted by Speid & Associates, Inc., in coordination with Harvard’s Office of Technology Development, and is a two-day intensive program for executive-level individuals that involves hands-on learning about the drug development process. 

Applied BioMath, LLC Announces Participation at PEGS: The Essential Protein Engineering Summit

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic systems modeling, simulation, and analysis to de-risk drug research and development, today announces their upcoming participation at PEGS: The Essential Protein Engineering Summit being held April 30 - May 4, 2018 in Boston, MA. Applied BioMath is sponsoring, exhibiting, presenting a poster, and presenting two talks at the conference.

Applied BioMath, LLC Announces Collaboration with Checkpoint Therapeutics for Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Modeling in Immuno-Oncology

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic mathematical modeling, simulation, and analysis to de-risk therapeutic research and development, today announced a collaboration with Checkpoint Therapeutics, Inc., for semi-mechanistic pharmacokinetic and pharmacodynamic (PK/PD) modeling in advanced metastatic solid tumors.   

Applied BioMath, LLC Collaborates with Xencor for Semi-Mechanistic PK/PD Modeling of XmAb®24306, Xencor's Lead IL15 Program for the Treatment of Solid Tumors

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to de-risk drug research and development, today announced a collaboration with Xencor to perform semi-mechanistic PK/PD modeling to analyze Xencor's XmAb® IL15/IL15Rα-Fc program for the treatment of solid tumors.  The collaboration will focus on developing a mathematical model relating XmAb®24306 modulated potency and extended half-life to observed pharmacokinetics and in vivo T-cell stimulation.

Applied BioMath, LLC Announces Collaboration with Pandion Therapeutics for Semi-Mechanistic Pharmacokinetic and Target Occupancy Modeling in Autoimmune Disease

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to accelerate and de-risk drug research and development, today announced a collaboration with Pandion Therapeutics for semi-mechanistic pharmacokinetic and target occupancy (PK/TO) modeling in Autoimmune Disease.

Applied BioMath, LLC Announces Pharmacokinetic and Pharmacodynamic Modeling Collaboration with Compass Therapeutics

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced a collaboration with Compass Therapeutics for the semi-mechanistic pharmacokinetic and pharmacodynamic (PK/PD) modeling of a therapeutic targeting solid tumors.  Semi-mechanistic PK/PD models will be developed for mouse, cynomolgus monkey, and human species and will help answer strategic questions such as the target coverage required for efficacy and dose regimen selection for the clinical study.

Registration is Open for QSP Industry & Academia Symposium

The QSP Industry & Academia Symposium is a seminar series for presenting, learning, and discussing topics relevant to quantitative systems pharmacology (QSP).The goal of this event is to foster an active community of industry and academic participants interested in these topics, and create a forum for sharing of successes and challenges.

Applied BioMath, LLC to Present at the Annual Drug Development Boot Camp`

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced their participation at the annual Drug Development Boot Camp November 15-16, 2017 at the Harvard Club in Boston, MA. The Drug Development Boot Camp is hosted by Speid & Associates, Inc., in coordination with Harvard's Office of Technology Development, and is a two-day intensive program for executive-level individuals that involves hands-on learning about the drug development process.

Applied BioMath, LLC Announces Collaboration with Syntimmune for Pharmacokinetic and Pharmacodynamic Modeling in Clinical Program for Autoimmune Diseases

Applied BioMath® (www.appliedbiomath.com), the industry leader in applying mechanistic modeling to drug research and development, today announced a collaboration with Syntimmune to provide semi-mechanistic pharmacokinetic and pharmacodynamic (PK/PD) modeling for Syntimmune's ongoing clinical trials.  Applied BioMath will deploy its Model-Aided Drug Invention (MADI) to analyze clinical data from Syntimmune's lead drug candidate, SYNT001.

Applied BioMath, LLC to Sponsor and Present at Antibody Engineering and Therapeutics Conference

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced their participation at the Antibody Engineering and Therapeutics Conference December 11-15, 2017 in San Diego, CA. John Burke, PhD, will present Model Aided Drug Invention (MADI) case studies on Thursday, December 14, 2017 at 12:00 p.m. In addition to speaking at the event, Applied BioMath is also participating as a scientific briefing sponsor. 

Applied BioMath, LLC to Present Case Studies on Model-Aided Drug Invention (MADI) at the American Conference of Pharmacometrics (ACoP)

Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling to drug research and development, today announced their participation in the upcoming American Conference on Pharmacometrics (ACoP) occurring October 15-18, 2017 in Fort Lauderdale, FL. Applied BioMath will be a conference sponsor, exhibitor, and poster presenter. Applied BioMath’s posters will highlight several examples of model-aided drug invention (MADI) by presenting case studies in immuno-oncology, osteoarthritis, and antibody-drug conjugates. More specifically, they will show: