The Essential Protein Engineering and Cell Therapy Summit

Event Details

May 11th - 13, 2021 | Virtual

Applied BioMath Presence

Presentation: Applied BioMath Assess™: An Early Feasibility Analysis Tool for Biotherapeutics

Presenter: John Burke, PhD, Co-Founder, President and CEO

Presentation Time: Tuesday, May 11th at 10:40 a.m.

Presentation Details:

Early R&D poses many questions and challenges when determining if a biotherapeutic enters the portfolio, and if so, what are its design characteristics? Some of the questions include an assessment of unmet medical need, competitive landscape, intellectual property, reimbursement, and difficulties of developability. Applied BioMath Assess is a new, interactive, web-based application that helps project leaders, protein engineers and chemists, and modelers assess the difficulties and risks in developing a therapeutic very early-on in a project.

Presentation: Optimizing multi-specific antibody design with mechanistic avidity models

Presenter: Lucia Wille, PhD

Presentation Time: Thursday, May 13th at 1:40 p.m.

Presentation Details:

Avid binding of multi-specific antibodies can confer desirable therapeutic properties, such as increased specificity to target cells. However, the design requirements and experimental interpretation are often counterintuitive. Mechanistic models provide clarity to guide development decisions (single-arm affinities, dosing) for desired functionality.