Mechanistic PKPD Models of Protein Therapeutics for Early Clinical Development
Fei Hua, Ph.D.; Daniel Kirouac, Ph.D.; Lore Gruenbaum, Ph.D.; John Burke, Ph.D.; Joshua Apgar, Ph.D. AAPS News Magazine (2018).
Quantitative Systems Pharmacology Model of hUGT1A1-modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler-Najjar Syndrome Type 1
Joshua F. Apgar , Jian-Ping Tang, Pratap Singh, Nanda Balasubramanian, John Burke, Michael R. Hodges, Melissa A. Lasaro, Lin Lin, Bjorn L. Miliard, Kristi Moore, Lucy S. Jun, Susan Sobolov, Anna Katharina Wilkins and Xiang Gao (2018).
A quantitative systems pharmacology model of colonic motility with applications in drug development
Raibatak Das, Lucia Wille, Liming Zhang, Chunlin Chen, Wendy Winchester, Jangir Selimkhanov, Jill Wykosky, Joshua F. Apgar, John M. Burke, Mark Rogge, Fei Hua, Majid Vakilynejad (2019).
Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody
Stroh M, Sagert J, Burke JM, Apgar JF, Lin L, Millard BL, Kavanaugh WM (2019).
PMID: 31250966
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis
Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N. (2015).
PMID: 26438154
An Introduction to the Regulatory and Nonclinical Aspects of the Nonclinical Development of Antibody Drug Conjugates
Lansita J. A., Burke J. M., Apgar J. F., Mounho-Zamora B. (2015).
PMID: 26108879