Scientific Leadership Team


John M. Burke, PhD

Co-Founder, President and CEO
Dr. Burke’s BS and MS are in Applied Mathematics from the University of Massachusetts, Lowell, in 1993 and 1995, respectively. His PhD degree is in Applied Mathematics from Arizona State University in 2003. His research interests include singularly and randomly perturbed differential equations, bifurcation theory, and applying dynamical systems theory to study and understand how cells and tissues make decisions in humans, and human disease. Prior to co-founding Applied BioMath, Dr. Burke joined... Read More

Joshua Apgar, PhD

Co-Founder and CSO
Before co-founding Applied BioMath, Josh was a Principal Scientist in the Systems Biology Group of the Department of Immunology and Inflammation at Boehringer Ingelheim Pharmaceuticals. His work leveraged physics-based models to: translate in vitro and in vivo data, assess target feasibility, understand drug mechanism of action, and predict human doses. The ultimate goal of this work was to reduce late stage attrition in drug development through a deep and quantitative interrogation of drug... Read More

Lore Gruenbaum, PhD

Executive Director of Biology and Pharmacology
Lore Gruenbaum is a biochemist and molecular biologist with 15 years of experience in drug discovery and clinical development of small and large molecules as well as diagnostics and personalized health care approaches. Lore was most recently employed as the Director of Biomarker Strategy, Infectious Diseases at the Roche Translational Clinical Research Center in New York City where she was responsible for drug target and biomarker identification, preclinical and clinical biomarker studies and... Read More

Fei Hua, PhD

Director of Modeling and Simulation
Dr. Fei Hua is a trained biologist and systems modeler with 11 years of drug discovery and development experience, working in a variety of disease areas with both large and small molecules. She previously worked at Pfizer Inc. in non-clinical groups to build systems biology models to help target differentiation, lead selection and biomarker identification. She then moved to the clinical group as a clinical pharmacology lead, where in addition to the traditional roles as clinical pharmacologist... Read More

Jim Hilbert, PhD

Senior Fellow
Jim received his Ph.D. in Medicinal Chemistry from the State University of New York at Buffalo in 1977. After receiving his Ph.D., Jim was a Postdoctoral Research Associate at the University of Kansas, studying the mechanism of Cytochrome P450 reactions. After his postdoc, Jim joined Schering-Plough Corporation in 1979 in non-clinical drug metabolism where he designed and executed non-clinical drug metabolism pharmacokinetic studies. In 1990, Jim joined Pfizer, Inc., where he started as a non... Read More

Dooyoung Lee, PhD

Senior Scientist
Prior to joining Applied BioMath, Dooyoung was a Scientist at FORUM Pharmaceuticals, Inc (Waltham, MA) where he worked on developing and implementing quantitative models in preclinical/translational development of medicines for serious brain diseases including PK/PD, Physiologically-Based PK and Systems Pharmacology. He has expertise in systems pharmacology modeling, mechanistic modeling and intracellular pathway modeling in biological systems. Dooyoung was a postdoctoral fellow in... Read More

Kumpal Madrasi, PhD

Senior Scientist
Kumpal received his Ph.D. in biomedical engineering from Florida International University where he started working on mathematical models exploring nitric oxide transport in the vasculature as nitrite and nitrosothiols. He did his fellowship at Mercer University working on modeling adherence of drugs for HIV and modeling uptake and activation of these drugs into peripheral blood mononuclear cells. He followed this up with another fellowship at University of Florida and FDA working on modeling... Read More

Andrew Matteson, PhD

Principal Scientist
Before joining Applied BioMath, Andrew was a Senior Software Engineer at The MathWorks where he worked on the SimBiology, Bioinformatics, and Machine Learning toolboxes. He has expertise in parameter estimation for biological systems, quantitative systems pharmacology, and machine learning. Andrew received his doctorate in computational biology from NYU's Courant Institute. Throughout his graduate work, Andrew worked closely with Merrimack Pharmaceuticals, providing computational and software... Read More

Bjorn Millard, PhD

Principal Scientist
Bjorn is a computational and systems biologist with a diverse set of experiences in pharma R&D and manufacturing. He previously worked at Silver Creek Pharmaceuticals in San Francisco, CA, using computational models to help engineer regenerative protein therapeutics. Prior to that, he was a modeling and simulation engineer with the RES Group in Needham, MA where he built and optimized organic synthesis reactor models for large pharma API manufacturing. He also spent two years at Merrimack... Read More

Anna Katharina Wilkins, PhD

Senior Scientist
Katharina holds graduate degrees in Biotechnology and in Chemical Engineering, having graduated from the Ecole Superieure de Biotechnologie de Strasbourg and from the Department of Chemical Engineering at MIT. Her doctoral work in advancing mathematical methods for the sensitivity analysis of oscillating systems, with particular application to biological systems such as the circadian clock, led to a more detailed functional understanding of the design of molecular networks. Other areas of... Read More

Katie Williams, PhD

Senior Scientist
Katie earned her PhD in Applied Mathematics from the University of Arizona this Spring with a dissertation titled "Anti-cancer treatment and the cell cycle: Cellular-level mathematical models." She also interned with Takeda Pharmaceuticals from 2014 - 2016 in both the Clinical Pharmacology and Modeling & Simulation departments where she developed mathematical models to support teams in many stages of drug development.

Carissa Young, PhD

Senior Scientist
Carissa earned a B.S. in Chemical Engineering from Georgia Tech in 2002 and a PhD from the University of Delaware in 2011, where she was awarded an NSF-IGERT fellowship in Biotechnology and NIH-sponsored institutional grants. As a systems biologist and protein engineer, Carissa’s prior research has focused on disease physiology, intracellular signaling, biomarker discovery, cell stress pathways, computational modeling, advanced microscopy, organ-on-chip platforms and protein and cellular... Read More

Lin Lin, PhD

Senior Scientist
Lin received a Bachelor of Science in Biomedical Engineering from Tsinghua University, China in 2009 and completed her PhD at University of Minnesota, Twin Cities in 2016. Her doctoral work focuses on modeling biological signal pathways and networks for use in understanding patterning and growth control in cell and tissue development. Her work also involves numerical PDE and ODE analysis, parameter estimation and sensitivity analysis. In addition to systems biology, she has hands-on experience... Read More

Ora Zyoto, PhD

Senior Software Engineer
Prior to joining Applied BioMath, Ora worked as a Research Scientist at NormaTec, where she designed clinical research protocols for a non-invasive medical device. More recently, she worked for MathWorks, first as an Advanced Support Engineer, then becoming a Senior Quality Engineer, where she supported SimBiology and the Bioinformatics toolbox. Ora earned her PhD in Biological Engineering from MIT, after having graduated from the Ecole Polytechnique (France). Her doctoral work focused on... Read More

David Hagen, PhD

Principal Software Engineer
David earned a B.S. and B.A. in Biochemistry and Economics from Case Western Reserve University in 2008 and a PhD in Biological Engineering from MIT in 2014. His graduate research focused on computational systems biology. Before joining Applied BioMath as a principal software engineer, he was an associate principal scientist at Merck.