Karyn came to Applied Biomath with 13 years of experience as an applied mathematician, working in both industry and academics. Her work heavily involved mathematical models of ordinary, partial, and delay differential equations, as well as some stochastic models. She has specialized in the use of inverse problems (e.g., parameter estimation, model selection, sensitivity and identifiability, etc.) to answer pertinent questions naturally arising in the life and social sciences. Most of her work has been in infectious disease dynamics (both at the population- and intrahost-levels) - the control thereof via therapeutics and vaccines, and the role of individual variability and social structure on estimates of transmission and subsequent control strategies. She has also worked on characterizing frequency-dependent intracellular calcium signaling via G protein coupled receptors, in addition to characterizing ligand-receptor binding kinetics, receptor internalization and upregulation, and resulting cellular responses, such as actin polymerization and oxidant production in human neutrophils.
Karyn held a tenured Associate Professor position in the Department of Mathematics at the University of Louisiana, as well as an adjunct appointment at Arizona State University through the Simon A. Levin Mathematical, Computational, and Modeling Sciences Center. She was the sole PI on a grant to study inverse problems in delay differential equations, and she directed a PhD Dissertation in modeling, estimation, and approximation in structured models (hyperbolic PDEs), in addition to other co-directing and mentoring experiences. She has given keynote and plenary addresses at international conferences, and several invited seminars at leading research institutions, as well as numerous invited conference talks. She was a senior research scientist at the Institute for Disease Modeling and did a post doc at the Center for Research in Scientific Computation at North Carolina State University. She earned her PhD in mathematics and M.A. in applied mathematics from Arizona State University, after completing her B.S. at the University of Michigan - Ann Arbor, where she double majored in mathematics and cell and molecular biology.