Event Details:
January 16th - January 19th | Hilton San Diego Bayfront
Applied BioMath Presence:
Presentation Title: Using Mathematical Modeling to Find a Balance Between Affinity & Avidity for an Optimal Therapeutic Window
Abstract:
- For cis-binding bispecific molecules, weaker single-target binding affinity with stronger avidity is used strategically to reduce the chances of the drug binding to off-target cells
- However, molecule development is more complicated once multiple targets (and affinities and avidities) are involved
- We will demonstrate how to develop a mechanistic PKPD model for bispecifics that capture the biophysics of binding and avidity, and how to use the model to predict optimal therapeutic window
Presenter: John Burke, PhD, Co-Founder, President, and CEO of Applied BioMath
Day and Time: Thursday, January 18th | 3:20pm PT