Systems Pharmacology and Mechanistic Modeling to Accelerate and De-risk Drug R&D

Fit-for-purpose model

"Applied BioMath’s modeling approach will be an important predictor of optimal dosing regimens to support potential future registration clinical trials for our targeted product candidates."
James F. Oliviero - Checkpoint Therapeutics

How We Are Unique

Our Modeling Approach

A rigorous fit-for-purpose model development process which quantitatively integrates knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms.

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Industry Experience

Over 100 years of cumulative industry experience spanning the entire therapeutic workflow from early research to clinical pharmacology and regulatory filings. 

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Proprietary Technology

Our modeling process, proprietary technology, and high-performance computing allow us to conduct large-scale simulations quickly and accurately, without having to take unnecessary shortcuts on the biology or the mathematics.

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Our Foundations

Mechanistic Modeling

Iterative Collaborations

Interdisciplinary Teams

The goal of this collaboration was to develop a QSP model to support translation from preclinical to clinical studies, and first-in-human (FIH) studies and to use this QSP model to provide a deeper understanding of the mechanisms of hUGT1A1-modRNA and to guide design of the first-in-human clinical studies.