Systems Pharmacology and Mechanistic Modeling to Accelerate and De-risk Drug R&D

Fit-for-purpose model

"Our collaboration with Applied BioMath will allow us to gain additional validation of our therapeutic's differentiated properties, particularly in regard to the dose level and dosing frequency."
David de Graaf, PhD - Syntimmune

How We Are Unique

Our Modeling Approach

A rigorous fit-for-purpose model development process which quantitatively integrates knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms.

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Industry Experience

Over 100 years of cumulative industry experience spanning the entire therapeutic workflow from early research to clinical pharmacology and regulatory filings. 

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Proprietary Technology

Our modeling process, proprietary technology, and high-performance computing allow us to conduct large-scale simulations quickly and accurately, without having to take unnecessary shortcuts on the biology or the mathematics.

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Our Foundations

Mechanistic Modeling

Iterative Collaborations

Interdisciplinary Teams

The goal of this collaboration was to develop a QSP model to support translation from preclinical to clinical studies, and first-in-human (FIH) studies and to use this QSP model to provide a deeper understanding of the mechanisms of hUGT1A1-modRNA and to guide design of the first-in-human clinical studies.