Biotherapeutic Model Pack

What's Included?

Applied BioMath Assess™ Biotherapeutic Model Pack includes 18 models covering 9 common pharmacologies (listed below). Each pharmacology has a 1-compartment model version and a 4-compartment model version. The 4-compartment models can easily be converted to a 3- or 2-compartment models by zeroing out distribution rates.

  • Monospecific Anti-Ligand
    • Bivalent antibody binding to soluble ligand
  • Monospecific Anti-Receptor
    • Bivalent antibody binding to membrane receptor
  • Bispecific Anti-Ligand x Anti-Ligand
    • Bivalent antibody binding to two different soluble ligands
  • Bispecific Anti-Ligand x Anti-Receptor
    • Bivalent antibody binding to soluble ligand and membrane receptor
  • Bispecific Anti-Receptor x Anti-Receptor
    • Bivalent antibody binding to two different membrane receptors
  • Bispecific Anti-Receptor x Anti-Ligand with Membrane Ligand x Receptor Competitor
    • Bivalent antibody binding to soluble ligand and membrane receptor with a membrane receptor and membrane ligand competitor
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Soluble Ligand Competitor
    • Bivalent antibody binding to two different membrane receptors with one membrane ligand and one soluble ligand competitor
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Membrane Ligand Competitor
    • Bivalent antibody binding to two different membrane receptors with two membrane ligand competitors
  • Monospecific Anti-Receptor with Membrane Ligand Competitor
    • Bivalent antibody binding to membrane receptor and membrane ligand competitor

 

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Model Resources

Each model in the Biotherapeutic Model Pack includes a mechanism of action diagram and a pharmacology diagram (Figure 1) with model parameters and their nominal values (Figure 2).

 

Figure 1: Model Diagrams

biotherapeutic model examples

Created with BioRender.com

Figure 2: Model Parameters

Each model in Applied BioMath Assess™ Biotherapeutic Model Pack has a unique set of parameters, a sample of which is shown here, based on the model pharmacology and number of compartments. More details on the full list of parameters are available upon request. In the app, each parameter contains a default value based on expansive literature searches and references.

biotherapeutic model parameters

Additional Model Packs

Avidity Model Pack: models covering both soluble and membrane ligand pharmacologies.

Learn more about our Avidity Model Pack

 

Gene Therapy Model Pack: 8 models covering LNP-encapsulated mRNA and siRNA therapies.

Learn more about our Gene Therapy Model Pack

 

Cell Engager Model Pack: models for solid tumors, in-vitro experiments, and solid tumors with 2 cell types.

Learn more about our Cell Engager Model Pack

 

Protein Degrader Model Pack: 4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.

Learn more about our Protein Degrader Model Pack