Applied BioMath Assess™ Model Libraries
Biotherapeutic Model Pack
Applied BioMath Assess includes 18 models covering 9 common pharmacologies (listed below). Each pharmacology has a 1-compartment model version and a 4-compartment model version. The 4-compartment models can easily be converted to a 3- or 2-compartment models by zeroing out distribution rates.
- Monospecific Anti-Ligand
- Bivalent antibody binding to soluble ligand
- Monospecific Anti-Receptor
- Bivalent antibody binding to membrane receptor
- Bispecific Anti-Ligand x Anti-Ligand
- Bivalent antibody binding to two different soluble ligands
- Bispecific Anti-Ligand x Anti-Receptor
- Bivalent antibody binding to soluble ligand and membrane receptor
- Bispecific Anti-Receptor x Anti-Receptor
- Bivalent antibody binding to two different membrane receptors
- Bispecific Anti-Receptor x Anti-Ligand with Membrane Ligand x Receptor Competitor
- Bivalent antibody binding to soluble ligand and membrane receptor with a membrane receptor and membrane ligand competitor
- Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Soluble Ligand Competitor
- Bivalent antibody binding to two different membrane receptors with one membrane ligand and one soluble ligand competitor
- Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Membrane Ligand Competitor
- Bivalent antibody binding to two different membrane receptors with two membrane ligand competitors
- Monospecific Anti-Receptor with Membrane Ligand Competitor
- Bivalent antibody binding to membrane receptor and membrane ligand competitor
Cell Engager Model Pack
(this requires the purchase of the biotherapeutic model pack)
- Cell Engager for Solid Tumors
- Tumor Cell Engager for In-vitro Experiments
- Effector Cell Engager for Solid Tumors with 2 Cell Types
Avidity Model Pack
(this requires the purchase of the biotherapeutic model pack)
- Monospecific Anti-Receptor with Avidity (4-Compartment)
- Bispecific Anti-Ligand x Anti-Receptor with Avidity (4-Compartment)
- Bispecific Anti-Receptor x Anti-Receptor with Avidity (4-Compartment)
- Bispecific Anti-Receptor x Anti-Ligand with Membrane Ligand x Receptor Competitor with Avidity (4-Compartment)
- Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Soluble Ligand Competitor with Avidity (4-Compartment)
- Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Membrane Ligand Competitor with Avidity (4-Compartment)
- Monospecific Anti-Receptor with Membrane Ligand Competitor with Avidity (4-Compartment)
Gene Therapy Model Pack
- LNP-encapsulated mRNA expressing an intracellular protein in vitro
- Two-compartment model of mRNA uptake, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an intracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP-encapsulated mRNA expressing an extracellular protein in vitro
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an extracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP- encapsulated siRNA expressing an intracellular protein in vitro
- LNP-encapsulated siRNA expressing an intracellular protein in vivo
- LNP-encapsulated siRNA expressing an extracellular protein in vitro
- LNP-encapsulated siRNA expressing an extracellular protein in vivo
Protein Degrader Model Pack
- PROTAC degrading an intracellular protein in vitro
- An in vitro model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vitro
- An in vitro model of a molecular glue degrader targeting and degrading intracellular proteins
- PROTAC degrading an intracellular protein in vivo
- An in vivo model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vivo
- An in vivo model of a molecular glue degrader targeting and degrading intracellular proteins
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