Applied BioMath Assess™ Model Libraries

Biotherapeutic Model Pack

Applied BioMath Assess includes 18 models covering 9 common pharmacologies (listed below). Each pharmacology has a 1-compartment model version and a 4-compartment model version. The 4-compartment models can easily be converted to a 3- or 2-compartment models by zeroing out distribution rates.

  • Monospecific Anti-Ligand
    • Bivalent antibody binding to soluble ligand
  • Monospecific Anti-Receptor
    • Bivalent antibody binding to membrane receptor
  • Bispecific Anti-Ligand x Anti-Ligand
    • Bivalent antibody binding to two different soluble ligands
  • Bispecific Anti-Ligand x Anti-Receptor
    • Bivalent antibody binding to soluble ligand and membrane receptor
  • Bispecific Anti-Receptor x Anti-Receptor
    • Bivalent antibody binding to two different membrane receptors
  • Bispecific Anti-Receptor x Anti-Ligand with Membrane Ligand x Receptor Competitor
    • Bivalent antibody binding to soluble ligand and membrane receptor with a membrane receptor and membrane ligand competitor
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Soluble Ligand Competitor
    • Bivalent antibody binding to two different membrane receptors with one membrane ligand and one soluble ligand competitor
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Membrane Ligand Competitor
    • Bivalent antibody binding to two different membrane receptors with two membrane ligand competitors
  • Monospecific Anti-Receptor with Membrane Ligand Competitor
    • Bivalent antibody binding to membrane receptor and membrane ligand competitor

Learn more about the Biotherapeutic Model Pack 

Cell Engager Model Pack

(this requires the purchase of the biotherapeutic model pack)

  • Cell Engager for Solid Tumors
  • Tumor Cell Engager for In-vitro Experiments
  • Effector Cell Engager for Solid Tumors with 2 Cell Types

Learn more about the Cell Engager Model Pack

Avidity Model Pack

(this requires the purchase of the biotherapeutic model pack)

  • Monospecific Anti-Receptor with Avidity (4-Compartment)
  • Bispecific Anti-Ligand x Anti-Receptor with Avidity (4-Compartment)
  • Bispecific Anti-Receptor x Anti-Receptor with Avidity (4-Compartment)
  • Bispecific Anti-Receptor x Anti-Ligand with Membrane Ligand x Receptor Competitor with Avidity (4-Compartment)
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Soluble Ligand Competitor with Avidity (4-Compartment)
  • Bispecific Anti-Receptor x Anti-Receptor with Membrane Ligand x Membrane Ligand Competitor with Avidity (4-Compartment)
  • Monospecific Anti-Receptor with Membrane Ligand Competitor with Avidity (4-Compartment)

Learn more about the Avidity Model Pack

Gene Therapy Model Pack

  • LNP-encapsulated mRNA expressing an intracellular protein in vitro
    • Two-compartment model of mRNA uptake, protein expression, and protein-mediated enzymatic reaction in vitro
  • LNP-encapsulated mRNA expressing an intracellular protein in vivo
    • Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
  • LNP-encapsulated mRNA expressing an extracellular protein in vitro
    • Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vitro
  • LNP-encapsulated mRNA expressing an extracellular protein in vivo
    • Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
  • LNP- encapsulated siRNA expressing an intracellular protein in vitro (coming soon)
  • LNP-encapsulated siRNA expressing an intracellular protein in vivo (coming soon)
  • LNP-encapsulated siRNA expressing an extracellular protein in vitro (coming soon)
  • LNP-encapsulated siRNA expressing an extracellular protein in vivo (coming soon)

Learn more about the Gene Therapy Model Pack

Protein Degrader Model Pack

  • in vitro PROTAC model
  • in vivo PROTAC model (coming soon)
  • in vitro Molecular Glue Degrader (MGD) model (coming soon)
  • in vivo Molecular Glue Degrader (MGD) model (coming soon)

Learn more about the Protein Degrader Model Pack

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