23rd Annual PepTalk

Event Details:

January 16th - January 19th | Hilton San Diego Bayfront 

Applied BioMath Presence:

Presentation Title: Using Mathematical Modeling to Find a Balance Between Affinity & Avidity for an Optimal Therapeutic Window


  • For cis-binding bispecific molecules, weaker single-target binding affinity with stronger avidity is used strategically to reduce the chances of the drug binding to off-target cells 
  • However, molecule development is more complicated once multiple targets (and affinities and avidities) are involved
  • We will demonstrate how to develop a mechanistic PKPD model for bispecifics that capture the biophysics of binding and avidity, and how to use the model to predict optimal therapeutic window

Presenter: John Burke, PhD, Co-Founder, President, and CEO of Applied BioMath

Day and Time: Thursday, January 18th | 3:20pm PT