Capturing CAR T-cell Therapy Dynamics Through Mechanistic Modeling

Webinar Details

Recorded on Tuesday, May 23, 2023.

Speaker: Sarah Minucci, PhD

Abstract: Chimeric antigen receptor T (CAR T)-cell therapy has shown remarkable success in treating various leukemias and lymphomas. CARs are engineered to redirect T cells to specific antigens. Much is still unknown about the workings of CAR-T cells in the body, and there is not a standard monitoring process. Modeling can shed light on CAR T-cell PK/PD and inform future studies. We developed a mechanistic model to capture CAR T-cell PK and validated our model with PD results. Our model can reproduce PD and provide information on characteristics of CAR T-cells and B cells that drive system dynamics. Furthermore, sensitivity analysis reveals patient and drug qualities that could improve tumor killing and subsequent outcome.


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