Improved Translation of Clinical TCE Dosing with Mechanistic Modeling

Webinar Details

Recorded on Thursday, July 20, 2023

Speaker: Marc Presler, PhD, Senior Principal Scientist at Applied BioMath 


  • Regulatory agencies recommend quantitative justifications for clinical dose selection.
  • T-cell engagers (TCE) pose particular challenges for dosing due to their multi-specific binding and avidity-based mechanism.
  • We present an improved mathematical model where the target doses are sensitive to the cell-surface density of TCE targets, rather than receptor concentration.
  • This model is robust to common discrepancies between experimental and clinical conditions, which often reduce accuracy of traditional models.


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