Applied BioMath, LLC Announces Collaboration with Sanofi for Systems Pharmacology Modeling of Bispecific Antibody Therapeutics

Applied BioMath (, the industry-leader in applying mechanistic modeling to drug research and development, today announced a collaboration with Sanofi for the analysis of systems pharmacology pharmacokinetic (PK)/target engagement (TE) models for bispecific antibody combinations.  Applied BioMath will help assess the risk and feasibility of multispecific combinations and compare them to fixed dose combinations (FDC) for multiple targets.  These analyses will be used to help prioritize the portfolio and provide early screening criteria for lead generation.  

"We are looking to quickly assess the feasibility of several bispecific combinations, as well as their FDC counterparts, to help prioritize our molecules based on our developability requirements," said Tom O'Shea, Head of North America DMPK at Sanofi. "Using Applied BioMath's approach, we plan to identify critical parameters which will help prioritize experiments, provide early indicators of what optimal drug properties would be for each molecule, and ultimately help us determine which molecules are best to pursue. Knowing early on what the optimal affinities, avidities, and half-lives, rather than after phase I or phase II, can potentially save millions of dollars up front, and potentially 100's of millions later."

"Taking a model based approach to design multispecific modalities challenges us to better understand our targets," said Jennifer Fretland, Head of Pharmacokinetic, North America DMPK at Sanofi.  "By understanding our targets and the interaction of our biotherapeutic with our targets, we can prioritize experiments and increase efficiency in discovery."

Applied BioMath leverages mathematics and high-performance computing to enable massive scale simulations in a very short time. "Model Aided Drug Invention (MADI) allows us to computationally explore numerous scenarios, including best-case and worst-case scenarios, for several molecules in a fraction of the time it would take to do the experiments in the lab," said Dr. John Burke, PhD, Co-Founder, President, and CEO of Applied BioMath.  "And because our modeling platform was designed specifically for biological modeling, we avoid shortcuts commonly used in other software platforms, which results in fast, accurate predictive analytics. This analysis can help assess risk and prioritize the early portfolio, and help set criteria to develop best-in-class multispecifics at the new targets stage or lead identification/lead generation stage, with the goal or reducing late stage attrition rates and helping our partners develop the best possible therapeutics, to ultimately better help patients, as quickly as possible."

About Applied BioMath

Founded in 2013, Applied BioMath uses mathematical modeling and simulation to provide quantitative and predictive guidance to biotechnology and pharmaceutical companies to help accelerate and de-risk drug research and development.  Their Model-Aided Drug Invention (MADI) approach employs proprietary algorithms and software to support groups worldwide in decision-making from early research through clinical trials.  The Applied BioMath team leverages their decades of expertise in biology, mathematical modeling and analysis, high-performance computing, and industry experience to help groups better understand their candidate, its best-in-class parameters, competitive advantages, patients, and the best path forward into and in the clinic.   For more information about Applied BioMath and its services, visit

Applied BioMath and the Applied BioMath logo are registered trademarks of Applied BioMath, LLC.

Press contact:
Kristen Zannella