Bhabuk Koirala, PhD LinkedIn

Senior Scientist, Modeling

Modeling & Simulation

Bhabuk received his Ph.D. in Biomedical Engineering from Old Dominion University in 2021. During his studies, he expanded a model that utilized partial differential equations to analyze near-infrared spectroscopy (NIRS) data from skeletal muscle during rest and contraction. The model described oxygen transport and metabolism in the skeletal muscles and distinguished the NIRS signals into their respective hemoglobin and myoglobin components.

During his graduate studies, Bhabuk completed an internship at DILIsym Services. He constructed PBPK models to predict the concentrations of compounds that could cause crystal formation in kidney tubules. He also worked on QSP/QST modeling to test different biological mechanisms in the liver in a pediatric population and compared the dynamics of several biomarkers with adult humans upon administration of different drugs.

After completing his studies, Bhabuk joined Janssen Pharmaceuticals as a translational PK PD scientist in the small molecule translational modeling team in 2021. He focused on developing (semi-mechanistic) PK PD models to help discovery teams optimize preclinical study design in oncology and immunology therapeutic areas.

Outside of work, Bhabuk pursues his passion for progressive rock as an aspiring guitarist. He also shows interest in exercise physiology and nutrition and tries to maintain a regular exercise routine.

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