Dr. Burke’s BS and MS are in Applied Mathematics from the University of Massachusetts, Lowell, in 1993 and 1995, respectively. His PhD degree is in Applied Mathematics from Arizona State University in 2003. His research interests include singularly and randomly perturbed differential equations, bifurcation theory, and applying dynamical systems theory to study and understand how cells and tissues make decisions in humans, and human disease.

Prior to co-founding Applied BioMath, Dr. Burke joined Boehringer Ingelheim in 2008 as Associate Director, Head of Systems Biology. In 2011, he was promoted to Senior Principal Scientist. At Boehringer Ingelheim, he started, developed and managed the Systems Biology group, portfolio, and strategy. The group was responsible for applying systems techniques to the drug discovery process across all Research sites, and supporting Development and Medicine. Prior to Boehringer Ingelheim, Dr. Burke was at Merrimack Pharmaceuticals, Co-Scientific Director of the Cell Decision Processes Center, Systems Biology Department, HMS, and was a Sr. Postdoctoral Fellow in Douglas A. Lauffenburger’s lab, Biological Engineering Department, MIT. While at MIT and HMS, Dr. Burke provided consulting or advising for various companies, including AstraZeneca, Pfizer, Momenta, Matlab, and RES Group. Presently he is on the advisory boards for the MIT “Human Physiome on a Chip” MIT-DARPA Program, and the Mathematics Department at the University of Massachusetts, Lowell.

    John M. Burke, PhD

    Key Research

    • Model-Informed Drug Development of the Masked Anti-PD-L1 Antibody CX-072
    • Fibrinolytic Therapy for Refractory COVID‐19 Acute Respiratory Distress Syndrome: Scientific Rationale and Review
    • QSP Model of Colonic Motility
    • Mechanistic PKPD Models of Protein Therapeutics for Early Clinical Development
    • Model Firsts: How QSP can Pick the Right Dose for First-in-Human Trials

    Interested in speaking with an expert?

    We'll put you in touch with the right person on our team. 

    Schedule Brief Consultation